For hydroxypropyl cellulose (E 463), the identified NOAEL corresponded to the highest dose 6,000 mg hydroxypropyl cellulose/kg bw per day (by gavage). The most relevant feeding studies with HPMC (E 464) were performed in rats which tolerated up to 10%, corresponding to 9,000 mg test item/kg bw per day. Rabbits tolerated up to 7,500 mg HPMC/kg bw per day administered via the diet (30 day exposure) and dogs up to 1,500 mg HPMC/kg bw per day, in either case being the highest tested dosages. More studies were conducted using sodium carboxy methylcellulose (E 466). The most relevant ones were conducted in rats, with NOAEL values ranging from 4,500 to 9,000 mg test item/kg bw per day (in all cases the highest dose tested). In these studies, some effects (caecum and colonic enlargement, urothelial hyperplasia, nephrocalcinosis, diffuse epithelial hyperplasia in the urinary bladder) were observed, however, not considered of toxicological concern: the findings in the gastrointestinal tract were considered to be a consequence of the accumulation of poorly absorbed water-soluble material and the findings in kidneys and urinary bladder were attributed to the up to fourfold higher concentration of sodium in the test diet compared with the basal diet. In one further study, rats were daily exposed (gavage) to doses equivalent to 0, 500, 2,500 or 5,000 mg/kg bw per day. Animals treated with ≥ 2,500 mg/kg bw per day had soft and pale faeces, which was attributed to the presence of test material and not considered of toxicological relevance. In the absence of any other adverse effects, also for this study, the identified NOAEL was the top dose (5,000 mg/kg bw per day).
Redispersible polymer powder, a unique and versatile material, finds extensive application across various industries due to its exceptional properties. This innovative product is essentially a dried form of polymer emulsion, which, when reintroduced to water, reconstitutes its original colloidal stability, thus the term redispersible. The construction industry also benefits from the use of HPMC due to its rheological properties. In paints and adhesives, HPMC ensures easy application by controlling the viscosity and preventing pigment settling. It also aids in the leveling and flow of cement mixtures in tile adhesives, resulting in a more uniform finish. In conclusion, while HPMC is generally considered safe for use in pharmaceuticals, cosmetics, and food products, there can be potential side effects associated with its use. These side effects can range from mild gastrointestinal discomfort to more serious allergic reactions. If you experience any side effects while using products containing HPMC, it is important to seek medical attention. As always, it is best to speak with your healthcare provider before starting any new products to ensure they are safe for you to use. Moreover, HPMC has environmental advantages. Being a non-toxic and biodegradable substance, it aligns with the increasing demand for eco-friendly construction materials. It does not release harmful chemicals during the setting process, ensuring a safer working environment for installers and occupants. Acetone and ethyl acetate, being polar aprotic solvents, can dissolve HPMC effectively due to their ability to disrupt the intermolecular forces within the polymer structureHPMC stands for hydroxypropyl methylcellulose or hypromellose for short. HPMC is the material from which most supplement capsules are made. It is a clear, tasteless, vegetarian and vegan appropriate material. It is normally made by extraction from wood pulp.
Since 1985, HPMC has been used as a gluten replacement for the manufacture of baked goods.3
The HS code, an international standard for customs tariffs and trade statistics, plays a crucial role in global trade. It is a six-digit numerical code that categorizes goods into specific product groups, making it easier for customs authorities to classify and levy duties on imported and exported goods. For HPMC, the HS code is critical for smooth international transactions and compliance with trade regulations. - Quality Certifications Ensure the product meets relevant quality standards, such as ISO or GMP, especially if it's for food, pharmaceutical, or medical use. 3. Cosmetics Industry HPMC is used as a thickener and film-forming agent in hair care products, skin creams, and other cosmetic formulations Cosmetics Industry HPMC is used as a thickener and film-forming agent in hair care products, skin creams, and other cosmetic formulationsMethyl cellulose and HPMC are both cellulose-based polymers, meaning they are nearly identical in chemical composition and structure. The main difference between the two is that HPMC has been modified with hydroxpropyl groups. HPMC is more water soluble and is therefore used in more industries than methyl cellulose. Methyl cellulose is more commonly used in food and cosmetics, while HPMC is more commonly used in pharmaceuticals and construction. In terms of application, however, there is very little difference between methyl cellulose and HPMC.
In the food industry, HPMC is commonly used as a food additive for its gelling, thickening, and emulsifying properties