At present, Lide powder is mainly produced in China. Most of the domestic Lide powder production is still using traditional methods. The main raw materials are zinc oxide, sulfuric acid and barium sulfide (barite and coal are produced by high temperature reduction). Zinc 45% ~ 70%. The traditional method for producing the Liede powder process is to use zinc bakelite containing more than 45% zinc as a raw material to be leached with sulfuric acid to obtain a crude zinc sulfate solution, and then to remove iron by potassium permanganate, and then replace the heavy metal with zinc powder and filter to obtain zinc sulfate. The refined liquid is further subjected to metathesis reaction, pressure filtration, calcination, rinsing, drying, and pulverization with strontium sulfide to obtain a series of different types of lindose powder containing zinc sulfide of 30% or more. The whole process is carried out in an acidic (ra<7) environment, which consumes a large amount of sulfuric acid. The sulfuric acid has strong corrosiveness and requires high production equipment. The final discharged slag is acidic slag, which brings new pollution to the environment. High requirements, high production costs, and poor quality of the products obtained.
Duan et al. administered 125 mg/kg BW or 250 mg/kg BW of anatase TiO2 (5 nm) intragastrically to mice continuously for 30 days. The exposed mice lost body weight, whereas the relative liver, kidney, spleen and thymus weights increased. Particles seriously affected the haemostasis of the blood and the immune system. The decrease in the immune response could be the result of damage to the spleen, which is the largest immune organ in animals and plays an important role in the immune response. Powel et al. demonstrated that TiO2 NPs may trigger immune reactions of the intestine after oral intake. They showed that TiO2 NPs conjugated with bacterial lipopolysaccharide, but not TiO2 NPs or lipopolysaccharide alone, trigger the immune response in human peripheral blood mononuclear cells and in isolated intestinal tissue. This indicates that TiO2 NPs may be important mediators in overcoming normal gut-cell hyporesponsiveness to endogenous luminal molecules, which may be particularly relevant to patients with inflammatory bowel disease, which is characterized by an abnormal intestinal permeability.