We've used titanium dioxide safely for decades. However, recently its safety was called into question.
At CRIS, we've explored the safety of titanium dioxide for nearly half a decade, including conducting double-blind research to test the safety of food-grade titanium dioxide (E171). Our study shows that when exposed to food-grade titanium dioxide in normal conditions, research animals did not experience adverse health outcomes.
It's important to emphasize that in a National Institutes of Health study, experimental animals were exposed to titanium dioxide in amounts as high as 5% of their diet for a lifetime and showed no evidence of adverse effects.
A handful of studies greatly influenced the decisions made by the European Food Safety Authority (EFSA). Unfortunately, these studies did not consider that titanium dioxide exposure comes from food, not drinking water. Additionally, CRIS researchers could not reproduce the adverse outcomes identified by the studies through typical food ingestion. Regardless, the EFSA banned E171 as a food ingredient and for use in other capacities in the summer of 2022.
In 2022, the United States, United Kingdom, and Canada maintained that the scientific evidence supports that titanium dioxide (E171) is safe for humans to use and consume.
According to data released by the China Coatings Industry Association, the total production of China's coatings industry has increased from 12.72 million tons in 2012 to 24.388 million tons in 2019, with a compound annual growth rate of 9.7%. Coatings, as an intermediate commodity, are closely related to downstream consumer markets such as the automotive industry, real estate, infrastructure, and home furnishings.
In a study published in the journal Toxicology, researchers examined the effects of exposing human colon cancer cell line (HTC116) titanium dioxide food additives in vitro. “In the absence of cytotoxicity, E171 was accumulated in the cells after 24 hours of exposure, increasing granularity and reactive oxygen species, inducing alterations in the molecular pattern of nucleic acids and lipids, and causing nuclei enlargement, DNA damage and tubulin depolymerization,” the scientists wrote. Researchers removed the additive from the culture, then examined the results 48 hours later. They found, “The removal of E171 was unable to revert the alterations found after 24 h of exposure in colon cells. In conclusion, exposure to E171 causes alterations that cannot be reverted after 48 h if E171 is removed from colon cells.”
First, the ammonia leaching method is used as a technical means for the effective treatment of acid leaching slag, and the nano nitrite powder is prepared under a weak alkaline ( Ή 8 8.5 to 10) ammonia environment. In an alkaline environment, some metal impurities such as The solubility of Ca, Mg, Fe and Al hydroxides is low, and the impurities entering the final immersion liquid in the selective leaching of ammonia-ammonium sulfate are reduced, thereby ensuring the quality of the product; the traditional acid method for preparing lithopone is because of the zinc calcination. In the roasting and reduction process of the alkalized alkali, the elemental sulfur and sulfite are more or less produced, and the prepared white powder has a yellowish color, and the metathesis reaction of the patent is carried out in an ammonia solution (alkaline). The final product obtained is sulfate, which is quickly and thoroughly added by desulfurization through 3⁄40 2 , and the whiteness of the product can be ensured without high temperature calcination; the equipment requirement is lower than that of sulfuric acid leaching, and the ordinary steel leaching tank can complete the leaching; The environmental pollution problem of acid leaching residue, especially effectively solves the environmental pollution of heavy metals such as zinc, copper, lead, cadmium and arsenic in acid leaching residue and the influence of acid ions on the storage environment. Realize the recycling of high-value metal zinc in acid leaching slag, realize the acidity improvement of soil and have the comprehensive advantages of low cost, energy saving and environmental protection.
Still, in 2016 Skittles publicly declared it would get rid of the chemical compound in its products, according to a press release at the time from the Center for Food Safety, which called the substance harmful and potentially poisonous. But the ingredient remains, according to the lawsuit, which alleges the candy company is misleading consumers by not having eliminated titanium dioxide.
These measures include tightened emission standards, increased penalties for non-compliance, and incentives for cleaner production technologies These measures include tightened emission standards, increased penalties for non-compliance, and incentives for cleaner production technologies